First report of an OXA-48-producing multidrug-resistant Proteus mirabilis strain from Gaza, Palestine.

نویسندگان

  • Liang Chen
  • Nahed Al Laham
  • Kalyan D Chavda
  • Jose R Mediavilla
  • Michael R Jacobs
  • Robert A Bonomo
  • Barry N Kreiswirth
چکیده

We report the first multidrug-resistant Proteus mirabilis strain producing the carbapenemase OXA-48 (Pm-OXA-48) isolated at Al-Shifa hospital in Gaza, Palestine. Draft genome sequencing of Pm-OXA-48 identified 16 antimicrobial resistance genes, encoding resistance to β-lactams, aminoglycosides, fluoroquinolones, phenicols, streptothricin, tetracycline, and trimethoprim-sulfamethoxazole. Complete sequencing of the bla(OXA-48)-harboring plasmid revealed that it is a 72 kb long IncL/M plasmid, harboring carbapenemase gene bla(OXA-48), extended spectrum β-lactamase gene bla(CTX-M-14), and aminoglycoside resistance genes strA, strB, and aph(3')-VIb.

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 59 7  شماره 

صفحات  -

تاریخ انتشار 2015